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Chiral Bis( N ‐arylamino)phosphine‐oxazolines: Synthesis and Application in Asymmetric Catalysis
Author(s) -
Schönleber Marc,
Hilgraf Robert,
Pfaltz Andreas
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800221
Subject(s) - chemistry , iridium , enantioselective synthesis , catalysis , oxazoline , phosphine , alkylation , alcohol , medicinal chemistry , organic chemistry , boron
N ‐Arylation or N ‐alkylation of chiral 1,2‐diamines followed by ring closure with phosphorus trichloride (PCl 3 ) and subsequent coupling with an oxazoline alcohol resulted in a new class of N,P ligands. The corresponding iridium tetrakis[3,5‐bis(trifluormethyl)phenyl]borate (BAr F ) complexes were found to be efficient catalysts for the enantioselective hydrogenation of unfunctionalized olefins and α,β‐unsaturated carboxylic esters.