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Candida antarctica Lipase B (CAL‐B)‐Catalyzed Carbon‐Sulfur Bond Addition and Controllable Selectivity in Organic Media
Author(s) -
Lou FengWen,
Liu BoKai,
Wu Qi,
Lv DeShui,
Lin XianFu
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800207
Subject(s) - candida antarctica , chemistry , thioether , markovnikov's rule , catalysis , selectivity , sulfur , lipase , organic chemistry , medicinal chemistry , combinatorial chemistry , regioselectivity , enzyme
A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL‐B)‐catalyzed carbon‐sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL‐B. Selectivity between anti‐Markovnikov addition and Markovnikov addition was achieved in different organic media. A series of thioether‐containing ester functional groups was synthesized under the catalysis of CAL‐B at 50 °C. All the products were characterized by spectroscopic methods (IR, NMR, ESI‐MS).