Novel Enantiocomplementary  C  2 ‐Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3,3,3‐Trifluoropyruvate | Zendy

Nakamura Shuichi | Zendy; Hyodo Kengo | Zendy; Nakamura Yuko | Zendy; Shibata Norio | Zendy; Toru Takeshi | Zendy

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Novel Enantiocomplementary C 2 ‐Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3,3,3‐Trifluoropyruvate

Author(s) -

Nakamura Shuichi,

Hyodo Kengo,

Nakamura Yuko,

Shibata Norio,

Toru Takeshi

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200800189

Subject(s) - chemistry , enantioselective synthesis , imidazoline receptor , friedel–crafts reaction , enantiomer , indole test , alkylation , organic chemistry , medicinal chemistry , stereochemistry , catalysis , medicine

Enantioselective Friedel–Crafts alkylations of a variety of indoles with ethyl 3,3,3‐trifluoropyruvate catalyzed by novel chiral m ‐phenylenebis(imidazoline)‐copper(II) complexes or the bis(imidazoline)‐achiral acid combination afforded products with high enantioselectivity. Both enantiomers of indole derivatives can be prepared with high enantioselectivities by tuning the N‐substituents of the imidazoline.

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