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Organocatalytic Asymmetric Formal [3+3] Cycloaddition Reactions of α,β‐Unsaturated Aldehydes with Nazarov Reagents
Author(s) -
Zhu MingKui,
Wei Qiang,
Gong LiuZhu
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800174
Subject(s) - chemistry , cycloaddition , reagent , organocatalysis , enantioselective synthesis , formal synthesis , combinatorial chemistry , organic chemistry , catalysis
An organocatalytic asymmetric formal [3+3] cycloaddition reaction of α,β‐unsaturated aldehydes with Nazarov reagents promoted by prolinol derivatives afforded, after oxidation, 3,4‐dihydropyranones in good yields with high enantioselectivities of up to 97% ee .
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