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Synthesis of Difurylmethane Derivatives via the Gold‐Catalyzed Tandem Cycloisomerization/Dimerization of Epoxide Alkynes
Author(s) -
Ji KeGong,
Shen YongWen,
Shu XingZhong,
Xiao HuiQuan,
Bian YongJiang,
Liang YongMin
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800130
Subject(s) - cycloisomerization , chemistry , epoxide , catalysis , tandem , tetrahydrate , combinatorial chemistry , organic chemistry , cascade reaction , crystal structure , materials science , composite material
A simple and convenient synthetic approach to difurylmethane derivatives has been developed via gold‐catalyzed cycloisomerization of 1‐oxiranyl‐2‐alkynyl esters and dimerization of the 2‐( α ‐hydroxyalkyl)furans. The reaction takes place in the presence of 2 mol% of tetrachloroauric acid tetrahydrate (HAuCl 4 ⋅4 H 2 O) under very mild conditions.