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Unmodified Nano‐Powder Magnetite Catalyzes a Four‐ Component Aza‐Sakurai Reaction
Author(s) -
Martínez Ricardo,
Ramón Diego J.,
Yus Miguel
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800089
Subject(s) - aldehyde , chemistry , catalysis , electrophile , ketone , magnetite , lewis acids and bases , combinatorial chemistry , organic chemistry , metallurgy , materials science
A new catalyst for an old material: magnetite is an excellent Lewis acid catalyst for the four‐component aza‐Sakurai reaction. The process could be repeated up to 15‐times without losing effectiveness, with the catalyst recycling being as easy as the use of a simple magnet. The catalyst is selective and could discriminate between aldehyde and ketone functionalities, catalyzing first the reaction with the higher electrophilic aldehyde.