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Rhodium‐Catalyzed Highly Regioselective Hydroformylation‐Hydrogenation of 1,2‐Allenyl‐Phosphine Oxides and ‐Phosphonates
Author(s) -
Guo Hao,
Ma Shengming
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800087
Subject(s) - hydroformylation , rhodium , chemistry , phosphine , regioselectivity , triphenylphosphine , medicinal chemistry , catalysis , toluene , carbon monoxide , hydride , organic chemistry , hydrogen
The rhodium‐catalyzed hydroformylation‐hydrogenation of 1,2‐allenyl‐phosphine oxides and ‐phosphonates is reported in this paper. The regioselectivity was well controlled, affording only saturated linear γ‐phosphinyl aldehydes under the standard conditions: (carbonyl)tris(triphenylphosphine)‐rhodium hydride [RhH(CO)(PPh 3 ) 3 ] (3 mol%), triphenylphosphine (PPh 3 ) (10 mol%), carbon monoxide (CO) (2.4×10 6 Pa), hydrogen (H 2 ) (subsequently charged to 4.8×10 6 Pa), toluene, 100 °C, 24 h.