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Highly Practical “Ligand‐Free‐Like” Copper‐Catalyzed N ‐Arylation of Azoles in Lower Nitrile Solvents
Author(s) -
Zhu Rui,
Xing Lixin,
Wang Xinyan,
Cheng Chuanjie,
Su Deyong,
Hu Yuefei
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700535
Subject(s) - chemistry , nitrile , ligand (biochemistry) , copper , denticity , catalysis , halide , aryl , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure , alkyl , receptor , biochemistry
In lower nitrile solvents, the N ‐arylation of azoles with aryl halides was achieved efficiently in the presence of copper powder without any additional ligands. Thus, the first nitrile type of monodentate ligand‐mediated, “ligand‐free‐like” copper‐catalyzed N ‐arylation procedure was established.
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