Premium
New Enantioselective Synthesis of Monofluorinated Pyridines Designed for the Preparation of Chemical Libraries
Author(s) -
Blayo AnneLaure,
Le Meur Stéphanie,
Grée Danielle,
Grée René
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700488
Subject(s) - chemistry , enantioselective synthesis , optically active , combinatorial chemistry , fluorine , organic chemistry , catalysis
Chiral pyridines with a fluorine atom in the benzylic position are easily accessible from optically active propargylic fluorides by using the Bohlmann–Rahtz reaction. Such pyridines, possessing four points of molecular diversity, are useful scaffolds for the preparation of chemical libraries.