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Aerobic Ligand‐Free Suzuki Coupling Reaction of Aryl Chlorides Catalyzed by In Situ Generated Palladium Nanoparticles at Room Temperature
Author(s) -
Han Wei,
Liu Chun,
Jin Zilin
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700475
Subject(s) - chemistry , palladium , aryl , catalysis , polyethylene glycol , suzuki reaction , ligand (biochemistry) , coupling reaction , peg ratio , nanoparticle , combinatorial chemistry , polymer chemistry , organic chemistry , nanotechnology , materials science , biochemistry , alkyl , receptor , finance , economics
An aerobic, ligand‐free Suzuki coupling reaction catalyzed by in situ generated palladium nanoparticles in polyethylene glycol with an average molecular weight of 400 Da (PEG‐400) at room temperature has been developed. This catalytic system is a very simple and highly active protocol for the Suzuki coupling of aryl chlorides with arylboronic acids, which proceed smoothly in excellent yields in short times using low catalyst loadings. Control experiments demonstrated that the Suzuki reaction catalyzed by the in situ generated palladium nanoparticles can be carried out much quicker than that using the preprepared particles under the same conditions. The formation of palladium nanoparticles in PEG‐400 was promoted by arylboronic acids.