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Catalytic Hydrogenation of α‐Iminophosphonates as a Method for the Synthesis of Racemic and Optically Active α‐Aminophosphonates
Author(s) -
Goulioukitaliya S.,
Bondarenko Grigorii N.,
Lyubimov Sergey E.,
Davankov Vadim A.,
Gavrilov Konstantin N.,
Beletskaya Irina P.
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700466
Subject(s) - chemistry , optically active , enantioselective synthesis , catalysis , binap , rhodium , asymmetric hydrogenation , noyori asymmetric hydrogenation , ligand (biochemistry) , chiral ligand , organic chemistry , combinatorial chemistry , hydrogen , catalytic hydrogenation , biochemistry , receptor
It was shown that the catalytic hydrogenation of α‐iminophosphonates by molecular hydrogen can serve as a convenient method for the synthesis of racemic and optically active α‐aminophosphonates. Up to 94% ee was achieved in the rhodium‐catalyzed enantioselective hydrogenation using chiral ligand ( R )‐BINAP.