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Direct Asymmetric Dynamic Kinetic Resolution by Combined Lipase Catalysis and Nitroaldol (Henry) Reaction
Author(s) -
Vongvilai Pornrapee,
Larsson Rikard,
Ramström Olof
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700432
Subject(s) - nitroaldol reaction , kinetic resolution , chemistry , lipase , yield (engineering) , transesterification , catalysis , enantioselective synthesis , enantiomeric excess , organic chemistry , enantiomer , enzyme , thermodynamics , physics
The asymmetric synthesis of β‐nitroalkanol derivatives was simply achieved by a combined nitroaldol (Henry) reaction with lipase‐catalyzed transesterification in high yield and enantiomeric purity (up to 92% and 99% ee ) through a direct one‐pot procedure.
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