Preparation the Key Intermediate of Angiotensin‐Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl ( R )‐2‐Hydroxy‐4‐Phenylbutyrate with  Candida boidinii  CIOC21 | Zendy

Chen Yongzheng | Zendy; Lin Hui | Zendy; Xu Xiaoying | Zendy; Xia Shiwen | Zendy; Wang Lixin | Zendy

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Preparation the Key Intermediate of Angiotensin‐Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl ( R )‐2‐Hydroxy‐4‐Phenylbutyrate with Candida boidinii CIOC21

Author(s) -

Chen Yongzheng,

Lin Hui,

Xu Xiaoying,

Xia Shiwen,

Wang Lixin

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200700420

Subject(s) - enantioselective synthesis , chemistry , phenylbutyrate , enzyme , angiotensin converting enzyme , fermentation , organic chemistry , biochemistry , stereochemistry , catalysis , medicine , blood pressure , radiology , endocrinology

Forty microorganisms belonging to different taxonomical groups were used to catalyze the enantioselective reduction of ethyl 2‐oxophenylbutyrate to afford the corresponding ethyl 2‐hydroxy‐4‐phenylbutyrate. Several microorganisms led to over 99% ee of ethyl ( S )‐2‐hydroxy‐4‐phenylbutyrate. Especially, we firstly found that the Candida boidinii CIOC21 could be effectively used for the enantioselective preparation the ethyl ( R )‐2‐hydroxy‐4‐phenylbutyrate in pure aqueous medium with 99% ee , a key intermediate in the production of angiotensin‐converting enzyme (ACE) inhibitors.

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