Continuous Flow Hydrogenation of a Pharmaceutical Intermediate, [4‐(3,4‐Dichlorophenyl)‐3,4‐dihydro‐2 H ‐naphthalenyidene]methylamine, in Supercritical Carbon Dioxide | Zendy

Clark Peter | Zendy; Poliakoff Martyn | Zendy; Wells Andy | Zendy

Premium

Continuous Flow Hydrogenation of a Pharmaceutical Intermediate, [4‐(3,4‐Dichlorophenyl)‐3,4‐dihydro‐2 H ‐naphthalenyidene]methylamine, in Supercritical Carbon Dioxide

Author(s) -

Clark Peter,

Poliakoff Martyn,

Wells Andy

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200700395

Subject(s) - chemistry , supercritical fluid , supercritical carbon dioxide , methylamine , catalysis , transfer hydrogenation , microreactor , imine , carbon dioxide , continuous flow , hydrogen , selectivity , chemical engineering , inorganic chemistry , organic chemistry , engineering , physics , ruthenium , mechanics

The hydrogenation of complex pharmaceutical intermediate, rac ‐sertraline imine has been optimized as a continuous flow process utilizing a palladium/calcium carbonate (Pd/CaCO 3 ) catalyst and hydrogen in supercritical carbon dioxide (scCO 2 ). Superior levels of selectivity were obtained in the flow system possibly attributable to the heat transfer properties of scCO 2 which help to remove excess heat from the catalyst surface.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research