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Continuous Flow Hydrogenation of a Pharmaceutical Intermediate, [4‐(3,4‐Dichlorophenyl)‐3,4‐dihydro‐2 H ‐naphthalenyidene]methylamine, in Supercritical Carbon Dioxide
Author(s) -
Clark Peter,
Poliakoff Martyn,
Wells Andy
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700395
Subject(s) - chemistry , supercritical fluid , supercritical carbon dioxide , methylamine , catalysis , transfer hydrogenation , microreactor , imine , carbon dioxide , continuous flow , hydrogen , selectivity , chemical engineering , inorganic chemistry , organic chemistry , engineering , physics , ruthenium , mechanics
The hydrogenation of complex pharmaceutical intermediate, rac ‐sertraline imine has been optimized as a continuous flow process utilizing a palladium/calcium carbonate (Pd/CaCO 3 ) catalyst and hydrogen in supercritical carbon dioxide (scCO 2 ). Superior levels of selectivity were obtained in the flow system possibly attributable to the heat transfer properties of scCO 2 which help to remove excess heat from the catalyst surface.