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Remarkable Efficiency Improvement in the Preparation of Insoluble Polymer‐Bound (IPB) Enantioselective Catalytic Systems by the Use of Silicone Chemistry
Author(s) -
Mandoli Alessandro,
Lessi Marco,
Pini Dario,
Evangelisti Claudio,
Salvadori Piero
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700359
Subject(s) - chemistry , enantioselective synthesis , hydrosilylation , oxazoline , cyclopropanation , catalysis , aldol reaction , organic chemistry , olefin fiber , polymer chemistry , silicone , combinatorial chemistry , covalent bond
The use of platinum‐catalyzed hydrosilylation chemistry of silicones greatly simplifies the preparation of bis‐oxazoline (box) ligands covalently bound to an insoluble polymeric support. The use of such immobilized chiral ligands in different copper‐catalyzed asymmetric transformations (carbonyl‐ene, Mukaiyama aldol and olefin cyclopropanation reactions) allows the attainment of high levels of enantioselectivity (91–99 % ee ).