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Highly Enantioselective Organocatalytic Conjugate Addition of Nitromethane to α,β‐Unsaturated Aldehydes: Three‐Step Synthesis of Optically Active Baclofen
Author(s) -
Zu Liansuo,
Xie Hexin,
Li Hao,
Wang Jian,
Wang Wei
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700353
Subject(s) - enantioselective synthesis , nitromethane , chemistry , conjugate , optically active , organocatalysis , aldol reaction , baclofen , combinatorial chemistry , organic chemistry , aldehyde , catalysis , mathematical analysis , biochemistry , receptor , mathematics , agonist
An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β‐unsaturated aldehydes has been developed. The process serves as the key step for a practical 3‐step synthesis of chiral baclofen, an antispastic drug.