Auto‐Tandem Catalysis: Synthesis of Substituted 11 H ‐Indolo[3,2‐ c ]quinolines  via  Palladium‐Catalyzed Intermolecular CN and Intramolecular CC Bond Formation | Zendy

Meyers Caroline | Zendy; Rombouts Geert | Zendy; Loones Kristof T. J. | Zendy; Coelho Alberto | Zendy; Maes Bert U. W. | Zendy

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Auto‐Tandem Catalysis: Synthesis of Substituted 11 H ‐Indolo[3,2‐ c ]quinolines via Palladium‐Catalyzed Intermolecular CN and Intramolecular CC Bond Formation

Author(s) -

Meyers Caroline,

Rombouts Geert,

Loones Kristof T. J.,

Coelho Alberto,

Maes Bert U. W.

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200700328

Subject(s) - chemistry , intramolecular force , tandem , intermolecular force , palladium , catalysis , ring (chemistry) , cascade reaction , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , molecule , materials science , composite material

D ‐Ring substituted 11 H ‐indolo[3,2‐ c ]quinolines ( 4 ) have been prepared via auto‐tandem consecutive intermolecular Buchwald‐Hartwig reaction and intramolecular palladium‐catalyzed arylation on 4‐chloroquinoline ( 1 ) with N ‐unsubstituted 2‐chloroanilines ( 2 ). The reported 11 H ‐indolo[3,2‐ c ]quinolines ( 4 ) represent the first examples in which tandem catalysis has been used to construct N ‐unsubstituted carbolines.

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