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Gold‐Catalyzed Tandem Cycloisomerization of Alkynyloxiranes with Nucleophiles: An Efficient Approach to 2,5‐Disubstituted Furans
Author(s) -
Shu XingZhong,
Liu XueYuan,
Xiao HuiQuan,
Ji KeGong,
Guo LiNa,
Qi ChenZe,
Liang YongMin
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700319
Subject(s) - cycloisomerization , chemistry , nucleophile , regioselectivity , catalysis , tandem , combinatorial chemistry , cascade reaction , reaction conditions , organic chemistry , medicinal chemistry , composite material , materials science
An efficient approach to 2,5‐disubstituted furans has been developed by utilizing gold‐catalyzed sequential nucleophilic attack onto metal‐complexed alkynes with complete regioselectivity. The reaction proceeds efficiently under mild conditions with commercially available catalysts to afford furans in moderate to excellent yields (up to 96 %) with high diversity.