2,3‐Disubstituted Benzo[ b ]thiophenes from Diarylalkynes  via  Electrophilic Addition‐Cyclization and Palladium‐Catalyzed Cross‐Coupling | Zendy

Lamanna Giuseppe | Zendy; Menichetti Stefano | Zendy

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2,3‐Disubstituted Benzo[ b ]thiophenes from Diarylalkynes via Electrophilic Addition‐Cyclization and Palladium‐Catalyzed Cross‐Coupling

Author(s) -

Lamanna Giuseppe,

Menichetti Stefano

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200700172

Subject(s) - chemistry , palladium , electrophile , catalysis , electrophilic addition , medicinal chemistry , combinatorial chemistry , double bond , coupling (piping) , stereochemistry , organic chemistry , mechanical engineering , engineering

Diarylalkynes are readily transformed in 3‐chlorobenzo[ b ]thiophenes in a two‐step electrophilic addition‐cyclization procedure that runs highly efficiently in solution or in the solid phase. The heteroaromatic carbon‐chlorine bond participates in palladium‐catalyzed Suzuki–Miyaura or Buchwald–Hartwig cross‐couplings to give, in a single step, 2,3‐disubstituted derivatives of pharmacological relevance .

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