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Chiral Thiourea‐Phosphine Organocatalysts in the Asymmetric Aza‐Morita–Baylis–Hillman Reaction
Author(s) -
Shi YongLing,
Shi Min
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700155
Subject(s) - methyl vinyl ketone , chemistry , bifunctional , thiourea , ketone , phosphine , baylis–hillman reaction , acrolein , thio , organic chemistry , catalysis , organocatalysis , enantioselective synthesis
A new kind of bifunctional (thio)urea‐phosphine catalyst was synthesized and applied to the aza‐Morita–Baylis–Hillman reaction of N ‐sulfonated imines with methyl vinyl ketone, phenyl vinyl ketone, ethyl vinyl ketone or acrolein. Moderate to excellent ee and yields of the products were obtained under mild reaction conditions.