Premium
PuPHOS and CamPHOS Ligands in the Intermolecular Catalytic Pauson–Khand Reaction
Author(s) -
Lledó Agustí,
Solà Jordi,
Verdaguer Xavier,
Riera Antoni,
Maestro Miguel A.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700145
Subject(s) - chemistry , intermolecular force , catalysis , ligand (biochemistry) , alkyne , pauson–khand reaction , selectivity , substrate (aquarium) , cobalt , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , molecule , receptor , biochemistry , oceanography , geology
Abstract The first asymmetric intermolecular cobalt‐catalyzed Pauson–Khand reaction is described. The use of the hemilabile CamPHOS ligand provides good conversions and selectivity up to 28 % ee . The catalytic process was studied by in situ FT‐IR and it was found that both bridged and non‐bridged complexes were present in the reaction mixture. Our results suggest that recognition between the alkyne substrate and the ligand is essential to attain stereocontrol in the catalytic cyclization.