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Laccase‐Mediated Deprotection of para ‐Methoxyphenyl (PMP)‐Protected Amines
Author(s) -
Verkade Jorge M. M.,
van Hemert Lieke J. C.,
Quaedflieg Peter J. L. M.,
Schoemaker Hans E.,
Schürmann Martin,
van Delft Floris L.,
Rutjes Floris P. J. T.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700060
Subject(s) - chemistry , laccase , combinatorial chemistry , solvent , organic chemistry , enzyme , scope (computer science) , computer science , programming language
A novel enzymatic procedure for the oxidative deprotection of p ‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP‐protected amines were successfully deprotected. The rate of deprotection was solvent‐ and pH‐dependent, and the reaction scope could be increased by using so‐called mediators.