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Nitrilase‐Catalyzed Enantioselective Synthesis of Pyrrolidine‐ and Piperidinecarboxylic Acids
Author(s) -
Winkler Margit,
Meischler Dorith,
Klempier Norbert
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700040
Subject(s) - enantioselective synthesis , chemistry , nitrilase , pyrrolidine , enantiomer , amide , enantiomeric excess , catalysis , amino acid , organic chemistry , proline , stereochemistry , nitrile , biochemistry
The enantioselective synthesis of the non‐proteinogenic amino acids β‐proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.