Premium
Heterogeneous Palladium Catalysts for a New One‐Pot Chemical Route in the Synthesis of Fragrances Based on the Heck Reaction
Author(s) -
Climent Maria Jose,
Corma Avelino,
Iborra Sara,
Mifsud Maria
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700026
Subject(s) - chemistry , palladium , catalysis , heck reaction , hydrotalcite , ketone , titanium dioxide , organic chemistry , magnesium , titanium , heterogeneous catalysis , selectivity , methyl vinyl ketone , chemical engineering , engineering
The one‐pot synthesis of the fragrance 4‐( p ‐methoxyphenyl)butan‐2‐one, with raspberry scent, has been carried out using palladium on different supports such as magnesium oxide (MgO), hydrotalcite, hydroxyapatite (HA), aluminium oxide (γ‐Al 2 O 3 ) and titanium dioxide (TiO 2 ). The first pathway consists of a Heck coupling between 4‐methoxyiodoanisole and methyl vinyl ketone followed by hydrogenation. Palladium supported on titanium dioxide showed the best performance for carrying out both consecutive steps giving 4‐( p ‐methoxyphenyl)butan‐2‐one with high yields and selectivity. The Pd‐TiO 2 catalyst is more active than a homogeneous palladium complex that is well accepted in the literature as being highly active for performing Heck reactions.