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Highly Enantioselective Synthesis of 3‐Hydroxy‐2‐methylpropanoic Acid Esters through Ruthenium‐SYNPHOS®‐Catalyzed Hydrogenation: Useful Building Blocks for the Synthetic Community
Author(s) -
Jeulin Séverine,
Ayad Tahar,
RatovelomananaVidal Virginie,
Genêt JeanPierre
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200700025
Subject(s) - enantioselective synthesis , chemistry , ruthenium , catalysis , enantiomer , organic chemistry , asymmetric hydrogenation , transformation (genetics) , atom economy , combinatorial chemistry , biochemistry , gene
Both enantiomers of 3‐hydroxy‐2‐methylpropanoic acid tert ‐butyl ester were prepared with high enantioselectivity (up to 94 %) through a ruthenium‐SYNPHOS®‐promoted asymmetric hydrogenation reaction using an atom‐economic transformation from simple and inexpensive precursors.