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Purification of Fluorous Mitsunobu Reactions by Liquid‐Liquid Extraction
Author(s) -
Curran Dennis P.,
Bajpai Reena,
Sanger Elizabeth
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200606187
Subject(s) - chemistry , reagent , partition coefficient , mitsunobu reaction , solvent , organic solvent , liquid–liquid extraction , extraction (chemistry) , chromatography , solvent extraction , organic chemistry , combinatorial chemistry , chemical engineering , engineering
Solvent tuning and partition coefficient measurements have identified suitable reagent and solvent combinations for the purification of fluorous Mitsunobu reaction products. The crude reaction mixtures are partitioned between 2/1 HFE‐7100/FC‐72 and DMF/10 % water to provide reagent (fluorous) and product (organic) fractions.