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Recyclable Selective Palladium‐Catalyzed Synthesis of Five‐, Six‐ or Seven‐Membered Ring Lactones and Lactams by Cyclocarbonylation in Ionic Liquids
Author(s) -
Ye Fangguo,
Alper Howard
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200606100
Subject(s) - palladium , chemistry , ionic liquid , catalysis , selectivity , ring (chemistry) , ligand (biochemistry) , ionic bonding , carbonylation , combinatorial chemistry , organic chemistry , medicinal chemistry , ion , carbon monoxide , receptor , biochemistry
The ionic liquids, BMIM PF 6 or BMIM NTf 2 , are used successfully for the palladium‐catalyzed cyclocarbonylation of 2‐allylphenols and anilines, 2‐vinylphenols, and 2‐aminostyrenes. The reaction proceeds cleanly and efficiently to afford high yields of lactones or lactams with good or excellent selectivity for one isomer. The ionic liquid containing the palladium catalyst, and ligand, is recyclable in all cases.