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Ruthenium‐Catalyzed Enantioselective Reduction of Electron‐Rich Aryl Alkyl Ketones
Author(s) -
Wettergren Jenny,
Bøgevig Anders,
Portier Maud,
Adolfsson Hans
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200606067
Subject(s) - chemistry , ruthenium , aryl , enantioselective synthesis , transfer hydrogenation , catalysis , alkyl , dipeptide , noyori asymmetric hydrogenation , selectivity , hydride , electron transfer , medicinal chemistry , combinatorial chemistry , organic chemistry , peptide , metal , biochemistry
Presented here is the investigation of the transfer hydrogenation of electron‐rich aryl alkyl ketones using ruthenium complexes of dipeptide‐like ligands and 2‐propanol as hydride source. The reduction proceeded with excellent selectivity (up to>99 % ee ) and in moderate to high yields (up to 90 %).