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Biocatalytic Racemization of α‐Hydroxy Ketones (Acyloins) at Physiological Conditions using Lactobacillus paracasei DSM 20207
Author(s) -
Nestl Bettina M.,
Kroutil Wolfgang,
Faber Kurt
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200606055
Subject(s) - racemization , chemistry , lactobacillus paracasei , isomerization , alkyl , aryl , organic chemistry , combinatorial chemistry , lactobacillus , catalysis , fermentation
Abstract Biocatalytic racemization of open‐chain and cyclic dialkyl‐, alkyl‐aryl‐ and diaryl‐substituted acyloins was accomplished using whole resting cells of Lactobacillus paracasei DSM 20207. The mild (physiological) reaction conditions ensured the suppression of undesired side reactions, such as elimination or condensation. This novel biocatalytic isomerization protocol represents an essential tool for the deracemization of pharmacologically important building blocks.