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Efficient Synthesis of 2‐Substituted Indoles Based on Palladium(II) Acetate/Tri‐ tert ‐butylphosphine‐Catalyzed Alkynylation/Amination of 1,2‐Dihalobenzenes
Author(s) -
Tang ZhenYu,
Hu QiaoSheng
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200606022
Subject(s) - chemistry , phenylacetylene , amination , palladium , iodobenzene , catalysis , alkynylation , palladium(ii) acetate , indole test , medicinal chemistry , organic chemistry , combinatorial chemistry
A simple, efficient palladium(II) acetate/tri‐ tert ‐butylphosphine‐catalyzed indole synthesis from o‐ alkynylhalobenzenes, readily available from 1,2‐dihalobenzenes, has been achieved in good to excellent yields. A one‐pot, Pd(OAc) 2 / t ‐Bu 3 P‐catalyzed sequential reaction from 1‐chloro‐2‐iodobenzene, phenylacetylene and amines has also been achieved in good yields.