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Synthesis of Polymer‐Supported Fesulphos Ligands and their Application in Asymmetric Catalysis
Author(s) -
MartínMatute Belén,
Pereira Susana Isabel,
PeñaCabrera Eduardo,
Adrio Javier,
Silva Artur M. S.,
Carretero Juan C.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600647
Subject(s) - chemistry , catalysis , allylic rearrangement , cycloaddition , ligand (biochemistry) , polystyrene , combinatorial chemistry , polymer , salt (chemistry) , polymer chemistry , 1,3 dipolar cycloaddition , organic chemistry , biochemistry , receptor
The synthesis of two Fesulphos‐based chiral ligands and their immobilization on a polystyrene support is described. These supported chiral ligands act as very efficient catalysts in 1,3‐dipolar cycloaddition and allylic substitution reactions providing the products with excellent enantioselectivities (91 to >99 % ee ). Filtration of the catalyst from the reaction mixtures allows simple product isolation. The polymer‐supported Cu complex of chiral ligand PS‐ 8 can be recycled without further addition of a copper salt in 1,3‐dipolar cycloaddition reactions.