Asymmetric 1,4‐Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2‐Aryltetralones | Zendy

Tokunaga Norihito | Zendy; Hayashi Tamio | Zendy

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Asymmetric 1,4‐Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2‐Aryltetralones

Author(s) -

Tokunaga Norihito,

Hayashi Tamio

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200600632

Subject(s) - chemistry , rhodium , diene , enantioselective synthesis , reagent , catalysis , ligand (biochemistry) , naphthoquinone , combinatorial chemistry , quinone , organic chemistry , stereochemistry , biochemistry , natural rubber , receptor

A novel synthetic approach to 2‐aryltetralones with high ee has been developed through asymmetric 1,4‐addition of arylboronic acids to naphthoquinone monoketals catalyzed by a rhodium complex with the ( R,R )‐Ph‐bod* ligand. The asymmetric addition proceeded in high yields with excellent enantioselectivity.

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