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Gold‐Catalyzed Efficient Formation of α , β ‐Unsaturated Ketones from Propargylic Acetates
Author(s) -
Yu Meng,
Li Guotao,
Wang Shaozhong,
Zhang Liming
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600579
Subject(s) - chemistry , catalysis , selectivity , reaction conditions , ketone , organic chemistry , medicinal chemistry , combinatorial chemistry
An efficient gold‐catalyzed method for the preparation of α , β ‐unsaturated ketones from propargylic acetates has been developed. Under mild reaction conditions, β ‐monosubstituted enones were formed mostly with excellent E ‐selectivity. β,β ‐Disubstituted enones can be prepared from propargylic acetates derived from ketones. The high efficiency and mild nature of this reaction render it a viable alternative for the synthesis of α, β ‐unsaturated ketones.