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Effects of Aromatic Substituents on Binaphthyl‐Based Chiral Spiro‐Type Ammonium Salts in Asymmetric Phase‐Transfer Reactions
Author(s) -
Kano Taichi,
Lan Quan,
Wang Xisheng,
Maruoka Keiji
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600576
Subject(s) - chemistry , alkylation , aldol reaction , enantioselective synthesis , catalysis , ammonium , glycine , phase (matter) , derivative (finance) , medicinal chemistry , stereochemistry , organic chemistry , amino acid , biochemistry , financial economics , economics
Spiro‐type phase‐transfer catalysts prepared from two equivalents of a single binaphthyl subunit were designed and applied to the asymmetric alkylation and direct aldol reactions of a glycine derivative. The effects of the substitution pattern of the binaphthyl subunits on the enantioselectivity were also investigated.