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Highly Efficient Threonine‐Derived Organocatalysts for Direct Asymmetric Aldol Reactions in Water
Author(s) -
Wu Xiaoyu,
Jiang Zhaoqin,
Shen HanMing,
Lu Yixin
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600564
Subject(s) - chemistry , aldol reaction , organocatalysis , enantiomer , threonine , organic chemistry , enantioselective synthesis , enantiomeric excess , catalysis , serine , enzyme
The introduction of siloxy groups at the hydroxy function of natural threonine resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of both cyclic and acyclic ketones with aromatic aldehydes in water with excellent enantiomeric excess.