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Tandem Catalysis: Access to Ketones from Aldehydes and Arylboronic Acids via Rhodium‐Catalyzed Addition/Oxidation
Author(s) -
Mora Guilhem,
Darses Sylvain,
Genet JeanPierre
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600530
Subject(s) - chemistry , aldehyde , rhodium , catalysis , tandem , acetone , ketone , organic chemistry , hydride , combinatorial chemistry , metal , materials science , composite material
Direct cross‐coupling reactions of aromatic aldehydes with arylboronic acids afforded ketones in high yields and under mild conditions in the presence of a rhodium catalyst, acetone and a base. This new reaction, involving a formal aldehyde CH bond activation, is believed to proceed via a tandem process involving addition of the organometallic species to the aldehyde followed by oxidation by β‐hydride transfer.