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An Efficient and Practical Method for Highly Chemoselective Hydrogenation of Nitrobenzylamines to Aminobenzylamine Hydrochlorides
Author(s) -
Cheng Chuanjie,
Wang Xinyan,
Xing Lixin,
Liu Bo,
Zhu Rui,
Hu Yuefei
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600521
Subject(s) - chemistry , hydrochloric acid , reactivity (psychology) , aqueous solution , chemoselectivity , palladium , carbon fibers , combinatorial chemistry , organic chemistry , catalysis , algorithm , computer science , medicine , alternative medicine , pathology , composite number
Aqueous hydrochloric acid proved to be a very reliable modulator for adjusting the reactivity of palladium on carbon. Thus an efficient and practical method for the highly chemoselective hydrogenation of N,N ‐dialkylnitrobenzylamines to amino‐ N,N ‐dialkylbenzylamine hydrochlorides was established. The method features convenient performance, easy work‐up and high efficiency.