A Thermostable Aldolase for the Synthesis of 3‐Deoxy‐2‐ulosonic Acids | Zendy

Lamble Henry J. | Zendy; Royer Sylvain F. | Zendy; Hough David W. | Zendy; Danson Michael J. | Zendy; Taylor Garry L. | Zendy; Bull Steven D. | Zendy

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A Thermostable Aldolase for the Synthesis of 3‐Deoxy‐2‐ulosonic Acids

Author(s) -

Lamble Henry J.,

Royer Sylvain F.,

Hough David W.,

Danson Michael J.,

Taylor Garry L.,

Bull Steven D.

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200600520

Subject(s) - aldolase a , chemistry , aldol reaction , stereochemistry , biocatalysis , combinatorial chemistry , biochemistry , enzyme , catalysis , reaction mechanism

A stereochemically promiscuous 2‐keto‐3‐deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C 3 ‐ and C 4 ‐aldoses to afford syn ‐ and anti ‐3‐deoxy‐2‐ulosonic acids in poor to good de . A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C 6 ‐ and C 7 ‐3‐deoxyhept‐2‐ulosonic acids to be produced in an efficient manner.

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