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A Highly Enantioselective Catalytic Domino Aza‐Michael/Aldol Reaction: One‐Pot Organocatalytic Asymmetric Synthesis of 1,2‐Dihydroquinolidines
Author(s) -
Sundén Henrik,
Rios Ramon,
Ibrahem Ismail,
Zhao GuiLing,
Eriksson Lars,
Córdova Armando
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600513
Subject(s) - enantioselective synthesis , domino , aldol reaction , chemistry , organocatalysis , catalysis , michael reaction , cascade reaction , organic chemistry , amine gas treating , combinatorial chemistry
The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the corresponding pharmaceutically valuable 1,2‐dihydroquinolines derivatives in high yields with 90 to >99 % ee .