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New Highly Effective Phosphite‐Phosphoramidite Ligands for Palladium‐Catalysed Asymmetric Allylic Alkylation Reactions
Author(s) -
Pàmies Oscar,
Diéguez Montserrat,
Claver Carmen
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600489
Subject(s) - phosphoramidite , chemistry , tsuji–trost reaction , moiety , ligand (biochemistry) , allylic rearrangement , alkylation , palladium , combinatorial chemistry , substrate (aquarium) , catalysis , organic chemistry , receptor , oceanography , geology , dna , biochemistry , oligonucleotide
We have designed a new family of readily available highly‐modular phosphite‐phosphoramidite ligands for asymmetric allylic alkylation reactions. The introduction of a phosphoramidite moiety in the ligand design is highly advantageous in the product outcome. Thus, this ligand series affords high reaction rates and enantioselectivities and, at the same time, shows a broad scope for disubstituted hindered and unhindered substrate types.