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New Ruthenium Catalysts for Asymmetric Transfer Hydrogenation of Prochiral Ketones
Author(s) -
Enthaler Stephan,
Hagemann Bernhard,
Bhor Santosh,
Anilkumar Gopinathan,
Tse Man Kin,
Bitterlich Bianca,
Junge Kathrin,
Erre Giulia,
Beller Matthias
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600475
Subject(s) - chemistry , ruthenium , transfer hydrogenation , enantioselective synthesis , catalysis , pyridine , triphenylphosphine , noyori asymmetric hydrogenation , organic chemistry , asymmetric hydrogenation , medicinal chemistry , combinatorial chemistry
Tridentate N,N,N ‐pyridinebisimidazolines have been studied as new ligands for the enantioselective transfer hydrogenation of prochiral ketones. High yields and excellent enantioselectivity up to >99 % ee have been achieved with an in situ generated catalytic system containing dichlorotris(triphenylphosphine)ruthenium and 2,6‐bis‐([ 4R,5R ]‐4,5‐diphenyl‐4,5‐dihydro‐1 H ‐imidazol‐2‐yl)‐pyridine ( 3a ) in the presence of sodium isopropoxide.