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Mesocellular Foam‐Supported Catalysts: Enhanced Activity and Recyclability for Ring‐Closing Metathesis
Author(s) -
Lim Jaehong,
Lee Su Seong,
Riduan Siti Nurhanna,
Ying Jackie Y.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600442
Subject(s) - chemistry , catalysis , ring closing metathesis , reusability , metathesis , ruthenium , leaching (pedology) , salt metathesis reaction , ligand (biochemistry) , combinatorial chemistry , homogeneous , heterogeneous catalysis , chemical engineering , metal , organic chemistry , polymer , biochemistry , physics , environmental science , receptor , thermodynamics , software , computer science , soil science , engineering , polymerization , soil water , programming language
Although ring‐closing metathesis (RCM) has been one of the most powerful methodologies for creating cyclic compounds, the pharmaceutical industry has not yet widely adopted this process commercially due to the high costs and leaching problems of homogeneous ruthenium catalysts. To circumvent these problems, we have immobilized the second‐generation Hoveyda–Grubbs catalyst effectively onto siliceous mesocellular foam (MCF). The open and interconnected pores of MCF facilitated ligand immobilization and substrate diffusion. We have observed that the ligand and metal loadings significantly affected the catalytic activity and recyclability. Enhanced recyclability by suppression of ruthenium leaching was achieved by using excess immobilized ligands. The resulting novel heterogenized catalysts demonstrated excellent activity and reusability for the RCM of various types of substrates.