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Highly Efficient Asymmetric Hydrogenation of α,β‐Unsaturated Carboxylic Acids Catalyzed by Ruthenium(II)‐Dipyridylphosphine Complexes
Author(s) -
Qiu Liqin,
Li YueMing,
Kwong Fuk Yee,
Yu WingYiu,
Fan QingHua,
Chan Albert S. C.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600410
Subject(s) - chemistry , ruthenium , cationic polymerization , catalysis , benzene , phos , asymmetric hydrogenation , medicinal chemistry , enantioselective synthesis , benzene derivatives , organic chemistry , chemical synthesis , biochemistry , in vitro
Abstract Two types of catalysts [RuL(benzene)Cl]Cl and Ru(OCOCH 3 ) 2 L with the dipyridylphosphine ligands P‐Phos and Xyl‐P‐Phos were applied in the asymmetric hydrogenation of α,β‐unsaturated carboxylic acids. The cationic complexes [RuL(benzene)Cl]Cl were found to be superior to the corresponding neutral complex Ru(OCOCH 3 ) 2 L in this type of reactions. The catalysts exhibited excellent activities and enantioselectivities (up to 97 % ee ) in the asymmetric hydrogenation.