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Gallium Trichloride‐Catalyzed Exhaustive α‐Ethynylation Reaction of 1‐Silylacetylenes
Author(s) -
Amemiya Ryo,
Yamaguchi Masahiko
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600399
Subject(s) - chemistry , propargyl , catalysis , gallium , enyne , organic chemistry , combinatorial chemistry , medicinal chemistry
Gallium trichloride (GaCl 3 ) catalyzes the ethynylation reaction of a 1,4‐enyne with chlorosilylacetylene at the propargyl position giving a triethynylvinylmethane. This catalytic method can be applied to the exhaustive α‐ethynylation of 1‐silylacetylenes possessing less acidic propargyl protons, and mono‐, di‐, and triethynylated products are obtained depending on the structure of the starting materials.