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An Efficient Cobalt( I )‐Catalysed Reformatsky Reaction using α‐Chloro Esters
Author(s) -
Lombardo Marco,
Gualandi Alessandra,
Pasi Filippo,
Trombini Claudio
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600378
Subject(s) - chemistry , cobalt , zinc , acetonitrile , catalysis , reformatsky reaction , iodide , chloride , metal , medicinal chemistry , organic chemistry
An efficient cobalt( I )‐catalysed Reformatsky reaction using α‐chloro esters has been developed. The catalyst is prepared by reducing the cobalt( II ) chloride (5 %)/1,2‐bis(diphenylphosphino)ethane (dppe)(5 %)/zinc iodide (10 %) system with zinc metal in acetonitrile in the presence of both the α‐chloro ester and the carbonyl compound; good to excellent conversions to β‐hydroxy esters are obtained at room temperature in 2.5 h.