Premium
Highly Efficient Asymmetric Hydrogenation of Alkyl Aryl Ketones Catalyzed by Iridium Complexes with Chiral Planar Ferrocenyl Phosphino‐Thioether Ligands
Author(s) -
Le Roux Erwan,
Malacea Raluca,
Manoury Eric,
Poli Rinaldo,
Gonsalvi Luca,
Peruzzini Maurizio
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600350
Subject(s) - thioether , asymmetric hydrogenation , iridium , phosphine , aryl , chemistry , alkyl , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis
Iridium complexes of planar‐chiral ferrocenyl phosphine‐thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ca. 250 h −1 . Furthermore, very high enantioselectivities (up to >99 %) together with complete conversions were obtained for the asymmetric hydrogenation of various acetophenones at 10 °C.