4‐Aryl‐2‐quinolones through a Pseudo‐Domino Heck/Buchwald–Hartwig Reaction in a Molten Tetrabutylammonium Acetate/ Tetrabutylammonium Bromide Mixture | Zendy

Battistuzzi Gianfranco | Zendy; Bernini Roberta | Zendy; Cacchi Sandro | Zendy; De Salve Ilse | Zendy; Fabrizi Giancarlo | Zendy

Premium

4‐Aryl‐2‐quinolones through a Pseudo‐Domino Heck/Buchwald–Hartwig Reaction in a Molten Tetrabutylammonium Acetate/ Tetrabutylammonium Bromide Mixture

Author(s) -

Battistuzzi Gianfranco,

Bernini Roberta,

Cacchi Sandro,

De Salve Ilse,

Fabrizi Giancarlo

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200600342

Subject(s) - chemistry , aryl , heck reaction , intramolecular force , domino , ammonium acetate , medicinal chemistry , bromide , phosphine , palladium , organic chemistry , catalysis , cascade reaction , alkyl , high performance liquid chromatography

4‐Aryl‐2‐quinolones can be prepared from readily available o ‐bromocinnamamide and aryl iodides using phosphine‐free palladium( II ) acetate as the precatalyst and a molten tetra( n ‐butyl)ammonium acetate/tetra( n ‐butyl)ammonium bromide mixture as the reaction medium. The reaction proceeds through a pseudo‐domino process involving two mechanistically independent, sequential catalytic cycles: a Heck reaction followed by an intramolecular Buchwald–Hartwig CN bond forming reaction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research