Premium
Oxapolycycles from One‐Pot Cross‐Metathesis/Carbonyl Ylide Formation‐Intramolecular Cycloaddition of α‐Diazo‐β‐keto Esters
Author(s) -
Hodgson David M.,
Angrish Deepshikha
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600306
Subject(s) - chemistry , intramolecular force , cycloaddition , diazo , ylide , tandem , metathesis , catalysis , intramolecular reaction , medicinal chemistry , organic chemistry , materials science , polymer , composite material , polymerization
Chemoselective cross‐metathesis of unsaturated α‐diazo‐β‐keto esters using Grubbs’ 2 nd generation catalyst, followed by Rh 2 (OAc) 4 ‐catalysed tandem carbonyl ylide formation‐intramolecular cycloaddition is demonstrated. The two different catalytic metallocarbene transfer reactions have also been successfully carried out in a one‐pot procedure, which allows rapid generation of molecular complexity in a single operation.