Oxapolycycles from One‐Pot Cross‐Metathesis/Carbonyl Ylide Formation‐Intramolecular Cycloaddition of α‐Diazo‐β‐keto Esters | Zendy

Hodgson David M. | Zendy; Angrish Deepshikha | Zendy

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Oxapolycycles from One‐Pot Cross‐Metathesis/Carbonyl Ylide Formation‐Intramolecular Cycloaddition of α‐Diazo‐β‐keto Esters

Author(s) -

Hodgson David M.,

Angrish Deepshikha

Publication year - 2006

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200600306

Subject(s) - chemistry , intramolecular force , cycloaddition , diazo , ylide , tandem , metathesis , catalysis , intramolecular reaction , medicinal chemistry , organic chemistry , materials science , polymer , composite material , polymerization

Chemoselective cross‐metathesis of unsaturated α‐diazo‐β‐keto esters using Grubbs’ 2 nd generation catalyst, followed by Rh 2 (OAc) 4 ‐catalysed tandem carbonyl ylide formation‐intramolecular cycloaddition is demonstrated. The two different catalytic metallocarbene transfer reactions have also been successfully carried out in a one‐pot procedure, which allows rapid generation of molecular complexity in a single operation.

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