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Palladium‐Catalyzed N ‐Arylation of N,N ‐Dialkylhydrazines with Aryl Chlorides
Author(s) -
Cacchi Sandro,
Fabrizi Giancarlo,
Goggiamani Antonella,
Sgalla Simona
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600299
Subject(s) - chemistry , aryl , palladium , ligand (biochemistry) , catalysis , medicinal chemistry , chloride , organic chemistry , biochemistry , alkyl , receptor
N,N ‐Dialkyl‐ N′ ‐arylhydrazines have been prepared usually in high to excellent yields via the reaction of N,N ‐dialkylhydrazines with aryl chlorides in the presence of Pd 2 (dba) 3 , Xphos and NaO‐ t‐ Bu in dioxane at 120 °C. With ortho ‐substituted aryl chlorides best results have been obtained by using 2‐(2′,6′‐dimethoxybiphenyl)dicyclohexylphosphine (ligand d) as the ligand.
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