Copper‐Catalyzed Enantioselective Conjugate Addition of Organometallic Reagents to Acyclic Dienones | Zendy

Šebesta Radovan | Zendy; Pizzuti M. Gabriella | Zendy; Minnaard Adriaan J. | Zendy; Feringa Ben L. | Zendy

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Copper‐Catalyzed Enantioselective Conjugate Addition of Organometallic Reagents to Acyclic Dienones

Author(s) -

Šebesta Radovan,

Pizzuti M. Gabriella,

Minnaard Adriaan J.,

Feringa Ben L.

Publication year - 2007

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200600272

Subject(s) - enantioselective synthesis , chemistry , phosphoramidite , conjugate , reagent , catalysis , metathesis , copper , combinatorial chemistry , salt metathesis reaction , organic chemistry , ring closing metathesis , medicinal chemistry , polymerization , dna , mathematical analysis , biochemistry , polymer , mathematics , oligonucleotide

The enantioselective, copper/phosphoramidite‐catalyzed 1,4‐addition of dialkylzinc reagents to acyclic dienones is described. The products of this reaction, obtained with enantioselectivities of up to 95 %, can be further functionalized by a second conjugate addition, or employed in an enolate trapping, ring‐closing metathesis protocol.

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