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Copper‐Catalyzed Enantioselective Conjugate Addition of Organometallic Reagents to Acyclic Dienones
Author(s) -
Šebesta Radovan,
Pizzuti M. Gabriella,
Minnaard Adriaan J.,
Feringa Ben L.
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600272
Subject(s) - enantioselective synthesis , chemistry , phosphoramidite , conjugate , reagent , catalysis , metathesis , copper , combinatorial chemistry , salt metathesis reaction , organic chemistry , ring closing metathesis , medicinal chemistry , polymerization , dna , mathematical analysis , biochemistry , polymer , mathematics , oligonucleotide
The enantioselective, copper/phosphoramidite‐catalyzed 1,4‐addition of dialkylzinc reagents to acyclic dienones is described. The products of this reaction, obtained with enantioselectivities of up to 95 %, can be further functionalized by a second conjugate addition, or employed in an enolate trapping, ring‐closing metathesis protocol.